A BAYESIAN ADAPTIVE FEASIBILITY DESIGN FOR RARE DISEASES

A Bayesian adaptive feasibility design for rare diseases

It is important for researchers to carefully assess the feasibility Spacecraft Model Kit of a clinical trial prior to the launch of the study.One feasibility aspect that needs to be considered includes whether investigators can expect to successfully achieve the sample size needed for their trial.In this manuscript, we present a Bayesian design in

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Predominance of Trypanosoma rangeli infection in children from a Chagas disease endemic area in the west-shore of the Panama canal

A total of 206 serum samples from children (3-14 years old) living in the Amador County (La Chorrera District, Province of Panama) were screened by indirect immunofluorescence antibody test (IFAT) for the presence of antibodies against Trypanosoma cruzi.Positive sera were confirmed by recombinant enzyme-linked immunosorbent assay (ELISA) and Servin

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Huge Epiglottic Cyst Presenting as Obstructive Sleep Apnoea

Epiglottic cysts are benign lesions which are either incidental findings or they presents as mild dysphagia and hoarseness or some Serving degree of respiratory obstruction.We report a rare case of adult male with huge epiglottic cyst presenting as obstructive sleep apnoea.A 50 years aged male presented with chief complain of loud snoring for one y

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Hate speech and hate-based harassment in online games

The proliferation of hate speech and hate-based harassment has become a worryingly common trend in online gaming spaces, with researchers fearing that it could lead to the Plastic Car normalization of hateful behaviors on such platforms.However, little research has been done assessing the frequency of such events and how players respond to their oc

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